General Surgery

Andreas Karachristos, MD, PhD, FACS

Professor, Clinical Surgery, Lewis Katz School of Medicine at Temple University
Chief, Hepatobiliary and Pancreatic Surgery, Temple University Hospital
Director, Hepatic Surgery, Fox Chase Cancer Center

About me

Clinical Interests
  • Hepatobiliary and pancreatic surgery
  • Neuroendocrine tumors of the pancreas
  • Chronic pancreatitis
  • Vena cava tumors and cancers involving the vena cava
  • Use of veno-veno bypass and in situ perfusion for massive liver tumors
  • Resection of primary liver cancers (hepatocellular carcinoma) and metastatic cancers to the liver
  • Open and minimally invasive (laparoscopic and robotic) surgery for liver tumors
  • Complex biliary reconstruction after bile duct injury
  • Complex venous and arterial reconstruction for liver and pancreatic tumors
  • Molecular analysis of liver lesions
  • Surgical therapy for benign and malignant diseases of the liver and bile ducts
Research Interests
  • Enhancing liver recovery after major resection
  • Quality improvement in hepatobiliary surgery

Panel Member, Hepatobiliary Cancers, National Comprehensive Cancer Network (NCCN)

  • Greek
  • MD, University of Crete School of Medicine, Greece
  • Fellowship, Organ Transplantation/Hepatobiliary Surgery, University of Cincinnati, Cincinnati, OH
  • Residency, General Surgery, Temple University Hospital, Philadelphia, PA
  • Residency, General Surgery, Yale New Haven Hospital, New Haven, CT
Board Certification
  • Surgery
  • American College of Surgeons
  • American Hepato-Pancreato-Biliary Association
  • International Hepato-Pancreato-Biliary Association
  • Society of Surgical Oncology
  • Society of Surgery of the Alimentary Tract
  • Pancreas Club
Awards and Honors
  • Diamond Award, Temple University Hospital, Abdominal Organ Transplant Program
  • Top Doctors, Surgery, Philadelphia magazine, 2018



1. Karachristos A, Linardopoulos S, Ergazaki M and Spandidos DA. Detection and analysis of hepatitis C virus by a combined RT-PCR method: variation in the 5’ non-coding region of the viral genome. J. Med. Microbiol. 42: 367-371, 1995.

2. Voulgarelis M, Chorti M, Kittas C, Karachristos A, Ikonomopoulos J, Skopouli FN. Fever and abdominal pain in a 45-year-old woman with cutaneous necrotising vasculitis. Clinical and Experimental Rheumatology 1998; 16: 72-76.

3. Karachristos A, Liloglou T, Field JK, Deligiorgi H and Spandidos DA. Microsatellite instability and p53 mutations in human hepatocellular carcinoma. Mol. Cell Biol. Res. Comm. 2, 155-161, 1999.

4. Mouzas IA, Fragkiadakis N, Moschandreas J, Karachristos A, Skordilis P, Kouroumalis E, Manousos ON. Validation and results of a questionnaire for functional bowel disease in out-patients. BMC Public Health. 2002 May 21;2(1):8.

5. Xinarianos G, Liloglou T, Prime W, Sourvinos G, Karachristos A, Gosney JR, Spandidos DA, Field JK. p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma. Int J Cancer. 2002 Sep 20;101(3):248-52.

6. Karachristos A., Scarmeas N., Hoffman J. CA 19-9 levels predict results of staging laparoscopy in pancreatic cancer. Journal of Gastrointestinal Surgery 2005 9(9): 1286-1292.

7. Jafri M., Tevar A., Lucia M., Thambi-Pillai T., Karachristos A., Buell J., Mark T., Hanaway M., Woodle S., Rudich S. Temporary Silastic Mesh closure for adult liver transplantation – A safe alternative for the difficult abdomen. Liver Transplantation 2007 13(2):258-65.

8. Karachristos A., Seamon M., Bradley k., Santora T., Abjit P., Goldberg A. The incidental Meckel’s diverticulum in trauma: A case report and literature review. J. Trauma Feb 12-2008.

9. Lee I, Constantinescu S, Gillespie A, Swami A, Birkenbach M, Leech S, Silva P, Karachristos A, Daller J, Sifontis N. Bortezomib as Therapy for Mixed Humoral and Cellular Rejection: Should it Be First Line? Clinical Transplants, 2009, 425-9.

10. Lee I, Constantinescu S, Gillespie A, Rao S, Silva P, Birkenbach M, Leech S, Karachristos A, Daller JA, Sifontis NM. Targeting alloantibody production with Bortezomib: Does it make more sense? Clin Transpl. 2010:397-403.

11. Karachristos A., Herrera A, Sifontis N, Darrrah J, Baribault G, Lee I, Leach S, Constantinescu S, Gaughan J, Jain A, Silva P, Daller J. Outcomes of renal transplantation in older high risk recipients. Is there an age effect? J Surg Res 1-6, 2010.

12. vonVital J, Karachristos A, Singhal A, Thomas R, Jain A, Acute Hepatotoxicity from Intravenous Amiodarone Following Liver Transplantation. Transplantation, 2011 91(8):e62-4.

13. Bhavsar T, Wang C, Huang Y, Karachristos A, Inniss S. Littoral Cell Angiomas of the Spleen Associated with Solid Pseudopapillary Tumor of the Pancreas World J GI Path 2011 3): 53-6.

14. Singhal A, Lander E, Karachristos A, Daly E, Dowling P, Patel P, Maloo M, Jain A Elevation of CA 125 and CA 19-9 in Patients with End Stage Liver Disease. Int J Biol Markers. 2012 Jul 19;27(2):e 147-51.

15. Singhal A, Karachristos A, Bromberg M, Daly E, Maloo M, Jain A Hypercoagulability in patients with End Stage Liver Disease: Prevalence and correlation with Severity of Liver Disease and Portal Vein Thrombosis. Clin Appl Thromb Hemost 2012 Nov;18(6):594-8.

16. Singla s, Warner A, Jain A,Thomas R, Karachristos A. Oriental cholangiohepatitis masquerading as cholangiocarcinoma. Int J Surg Case Rep. 2012;3(7):235-7.

17. Mukerji AN, Tseng E, Karachristos A, Maloo M, Jain A. Chylous ascites after liver transplant: case report and review of literature. Exp Clin Transplant. 2013 Aug;11(4):367-74. doi: 10.6002/ect.2012.0203. Epub 2013 May 12.

18. Singhal A, Mukerji AN, Thomaides A, Karachristos A, Maloo M, Sanchez B, Keresztury M, Santora TA, Jain A. Chronotropic incompetence on dobutamine stress echocardiography in candidates for a liver transplant. Exp Clin Transplant. 2013 Dec;11(6):546-53.

19. Mukerji AN, Karachristos A, Maloo M, Johnson D, Jain A. Do postliver transplant patients need thromboprophylactic anticoagulation? Clin Appl Thromb Hemost. 2014 Oct;20(7):673-7.

20. Karachristos A, Esnaola NF. Surgical management of pancreatic neoplasms: what's new? Curr Gastroenterol Rep. 2014 Aug;16(8):397. doi: 10.1007/s11894-014-0397-x.

21. Jain A, Constantinescu S, Maloo M, Mukerji AN, Karachristos A, Lau K, Di Carlo A. Delayed introduction of tacrolimus postliver transplant with intravenous mycophenolate mofetil preserves renal function without incurring rejection. Transplantation. 2014 Oct 15;98(7):e68-70.

22. Maranki J, Meyer J, Karachristos A, Denlinger C, Esnaola N. Evaluation and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma. Cancer 2016 May 1;122(9):1349-69.

Books, Monographs, Chapters
1. Karachristos A. Benign and Malignant Liver Lesions. In: Mont Reid Surgical Handbook, 2007.

2. Karachristos A., Parikh A. Management of locally advanced pancreatic cancer. In: Advanced Therapy in Surgical Oncology, 2008. Editors: Pollock R., Curley S., Ross M., Perrier N.

3. Karachristos A, Tevar A, Kim DS, Buell J, Woodle ES, Rudich S. Laparoscopic right living donor hepatectomy. In Living Donor OrganTransplantation, 2008. Editors: Rainer W. G. Gruessner and Enrico Benedetti.

4. Karachristos A. SCORE (Surgical Council on Resident Education) peer reviewed web publication, authoring Hepatic Neoplasms- Benign, Hepatic Neoplasms – Metastatic, Hepatic Neoplasms – Malignant, Cirrhosis/Portal Hypertension (Ascites), Hepatic Ultrasound – Intraoperative, Segmentectomy/Lobectomy - Open.

Ratings & Reviews


Our Patient Satisfaction Rating is an average of all responses to care provider related questions from our nationally-recognized Press Ganey Patient Satisfaction Survey. Learn more.


4.7 / 5.0


  • 4.7
  • 4.6
  • 4.8
  • 4.9
  • 4.6


  • 5.0
    September 24, 2018
    Very gracious, even though he was not feeling 100%.
  • 5.0
    June 28, 2018
    my daughter-in-law brings me to my appointments so she can hear what the doctor says. every doctor and nurse is very patient with us, answering every question and explaining each answer for both of us.
  • 4.5
    June 23, 2018
    Dr. Karachristos is kind & gentle with his delivery about issues, the best.